Beta 1,3D Glucan

What is Beta Glucan?

Some of the sources beta glucan is derived from are Yeast (Saccharomyces cerevisiae), Mushrooms, Bacteria, Seaweed, Cereal grains (oats). Our highly purified beta glucan is a derivative of baker’s yeast. The most extensively studied glucan, perhaps because it has been proven to produce the highest biological effects.

Beta glucan is a Natural polysaccharide, existing in numerous molecules of glucose bound together in several types of linkages. Beta glucan is a Natural immune-modulator (sometimes called biological response-modifier). The molecule activates all of the body’s immune cells: Macrophages, Neutrophils, Basophils, Natural Killer Cells, etc.

Macrophages, directly, influence a number of immune functions that allow the body to achieve a significantly higher and effective immune response. The activity of the body’s Immune Cells (immunocytes) determines how well the Immune System targets foreign pathogens that do not belong in the body. (e.g., Viruses, Bacteria, Fungi, Cancer, Parasites, etc.). Beta glucan will activate this process and make the immune system more efficient and better trained in order to create a more efficient immune response.

How DOES Beta Glucan Work?

Mechanism of Action in the Body

In general, Insoluble Whole Glucan Particulate (Beta Glucan) once swallowed, passes through the stomach into the small intestine uptake via the Peyer’s patches. Macrophages then transport the beta glucan to immune organs throughout the body through the reticuloendothelial system via the lymphatic system. In more detail, Beta glucan is engulfed or phagocytosed by macrophages, innate immune cells that are part of the body’s first line defense. The macrophages break down the beta glucan into smaller particles and secrete beta glucan fragments that bind to certain receptors on the surface of neutrophils, the most abundant immune cell in the body.

For neutrophils to kill a foreign challenge, a receptor on its surface called CR3 must be occupied by both complement, a blood protein, and beta glucan. This occurs naturally in the presence of some challenges, such as fungal infections. But for other challenges, including cancer and many infectious diseases, beta glucan is not present. Taking β1,3-D beta glucan provides the beta glucan needed to occupy the second binding site and trigger annihilation.

Immuno-stimulation by beta glucan has been demonstrated using the following: Shrimp, Fish, Chicken, Mice, Rats, Rabbits, Guinea Pigs, Sheep, Pigs, Horses and Humans.

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